City will be hoping for a third successive home derby victory and to put a major dent in United's title ambitions for the second year running.
Three points would also boost City's chances of climbing into the European places.
As for the visitors, they are in hot pursuit of runaway leaders Chelsea and are eager to keep up the chase.
City's 0-0 draw at Stamford Bridge was a good result for the Blues but perhaps even better for United as it gives them a much-needed glimmer of hope as they aim to catch up with Jose Mourinho's men.