United already have the league title in the bag, but victory for Asa Hartford's City side will secure them a second-place finish.
City's second string won the reverse fixture back in November when a Bradley Wright-Phillips goal sealed the points.
They will field a young line-up this evening, which includes Paul Collins and Ian Bennett, who both signed new contracts today that will keep them at the club until the end of next season.
Even after tonight, there is still another Manchester derby in store this season with City and United's reserves going head-to-head in the final of the Manchester Senior Cup on Monday May 9 (ko:7.30pm @ CoMS).
City: Nicky Weaver, James-Lee Matthews, Danny Warrender, Christian Negouai, Micah Richards, Paul Collins, Willo Flood, Ian Bennett, Karl Bermingham, Ishmael Miller, Marc Laird.
Subs: Jonathan D'Laryea, Kevin Ellegaard, Michael Johnson, Ashley Grimes, Kelvin Etuhu.