The Spurs defender is looking forward to Sunday's live Sky Sports clash at White Hart Lane, when seventh will host eighth.
City have struggled on their domestic travels so far this season, losing at Cardiff, Aston Villa, Chelsea and Sunderland.
However, Spurs have suffered surprise home defeats to West Ham and Newcastle so the weekend duel looks hard to call.
Jan Vertonghen: "It's really crazy.
"I think if we'd won against Newcastle, we'd be joint second now - but we're seventh.
"It's unbelievable how we play City and United next. It's very hard this year. (Vincent) Kompany already said it will be the toughest league in years to finish top. We have to be at our best to finish in the top four.
"City I think is the best team in the league.
"Arsenal are doing very well of course. But especially in home games, City is the team to beat."