The City keeper will be up against former England team-mate Alan Shearer. He, along with Jonathan Woodgate and Keiron Dyer, returns for Newcastle after a spell out with injury.
Trevor Sinclair also returns for City after suffering from a dead leg.
Shaun Wright-Phillips is unavailable as he is serving the last game of his suspension. Claudio Reyna and Danny Tiatto are both ruled out with hamstring injurys.
Anelka and Fowler will start up front as Paulo Wanchope is being rested after playing for Costa Rica against Finland earlier this week.