The Argentine striker signed for Manchester City for ?35million but is suffering from foot blisters and has been unable to train.
Hampered: Striker Sergio Aguero is suffering from blisters on his foot
And according to The Sun, the former Atletico Madrid frontman will have to settle for a place on the bench.
His international team-mate Carlos Tevez, who is still seeking a move away from the Etihad Stadium, remains on holiday until Monday.
Staying away: Carlos Tevez is on holiday until Monday
That leaves City boss Roberto Mancini with a strike force of Mario Balotelli and Edin Dzeko for the Wembley showdown.
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Source: Daily Mail
Source: Daily Mail