The Toure brothers, midfield star Yaya and defender Kolo, are preparing for the African Nations Cup with Ivory Coast, striker Aguero has a hamstring injury and former Arsenal playmaker Nasri is suspended.
Defender Aleksandar Kolarov is back in contention but Maicon, Micah Richards and Jack Rodwell are still sidelined.
Roberto Mancini: "We can do nothing - Yaya is in South Africa but the problem is we are missing three or four important players, Samir, Sergio and the others.
"But I think if we work hard we can do well.
"Yes, we have had a lot of injuries this year. Last year we were really lucky, this year maybe not.
"We have had important players injured but this is football. We need to work, we need to work with players we have.
"We should take one or two young players because we have 16 and we hope we can recover injured players for next week."