Tottenham expect the PFA's Player of Year Gareth Bale to miss the rest of the season with an ankle injury.
They are also sweating on the fitness of playmaker Luka Modric and striker Peter Crouch.
Manchester City
Doubtful: Tevez (hamstring), Zabaleta (unspecified)
Injured/unavailable: Boateng & M Johnson (both knee), Given (shoulder), K Toure (club suspension)
Tottenham
Doubtful: Crouch (back), Modric (hip)
Injured: Assou-Ekotto (hamstring), Bale & Huddlestone (both ankle), Hutton & Palacios (both knee), Khumalo (foot), King (groin), Woodgate (calf)
MATCH PREVIEW
Manchester City go into this match with the chance to exact sweet revenge over a Tottenham side whose famous win at the City of Manchester Stadium almost exactly a year ago denied them a Champions League spot.
This is a very important week for the club, the players and the fans. This is do or die for Manchester City
Man City midfielder Nigel de Jong
Even if Roberto Mancini's side lose, they will still hold a three-point buffer over Spurs and are clear favourites to secure a first ever appearance in Europe's premier club competition next season.
And with the FA Cup final against Stoke looming on Saturday, this could be a truly momentous week in the history of the club.
As for Tottenham, the stagnation of their season continued at the weekend against Blackpool and manager Harry Redknapp admits the battle for fourth place has all but gone.
They face a fight with Liverpool, who they face at Anfield on Sunday, to reach the Europa League. But Redknapp readily admits it is a competition he is not keen for his team to compete in next season.
MATCH FACTS
Head-to-head
• Tottenham have won 19 Premier League matches against Manchester City. Only Arsenal, with 20, have beaten City on more occasions.
• Spurs have beaten City in 11 out of their last 13 matches in the league.
• Eight of the last 12 Premier League matches between the sides have ended 2-1.
Manchester City
• City have lost only twice at home in all competitions since they were defeated by Tottenham on 5 May last year.
• Carlos Tevez has scored more league goals (19) than Tottenham strikers Jermain Defoe (4), Peter Crouch (4) and Roman Pavlyuchenko (8) combined.
Tottenham
• Tottenham have won only one of their last 12 matches in all competitions.
• Harry Redknapp's side have drawn six out of their last eight games.
• Only Arsenal, Chelsea and Manchester City have won more matches away from home this season than Tottenham's six.
LEADING GOALSCORERS
Manchester City
Tevez: 22 goals (19 league); Balotelli: 10 goals (6 league)
Tottenham
Van der Vaart: 14 goals (12 league); Pavlyuchenko: 12 goals (8 league)
MATCH OFFICIALS
Referee: Mike Dean
Assistant referees: Peter Kirkup & Mike Mullarkey
Fourth official: Stuart Attwell
LAST LEAGUE MATCH LINE-UPS
Man City (L1-2 v Everton, a): Hart; Zabaleta (Balotelli 81), Kompany, Lescott, Kolarov, De Jong (Jo 89), Vieira (A Johnson 78), Milner, Y Toure, Silva, Dzeko. Subs not used: Given, Wright-Phillips, Boyata, McGivern.
Tottenham (D1-1 v Blackpool, h): Gomes; Kaboul, Gallas, Dawson, Bale (Crouch 64), Van der Vaart, Modric, Sandro, Rose (Kranjcar 90), Pavlyuchenko (Lennon 46), Defoe. Subs Not Used: Cudicini, Jenas, Bassong, Corluka.
Source: BBC Sport
Source: BBC Sport