However, they will be aware that David Moyes' team have the upper hand over them in recent meetings, winning four of their last five matches against City while none of the 12 Premier League clashes between the sides in Manchester have ended in a draw.
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However, City are unbeaten at home in the league for almost 12 months and have conceded only one goal in their last five league games at Eastlands.
Everton's form has been superb since the turn of the year and they would be third in the table if the season had started on New Year's Day.
Most of the Toffees' recent points have come at Goodison Park though as they have won all seven of their league matches since Boxing Day while taking only one point from a possible nine since beating Wigan Athletic at the DW Stadium in January.
However, as Liverpool continue to falter, Moyes' men have the incentive of possibly finishing above the Reds this season. A win on Wednesday would leave them only three points behind Rafa Benitez's team with seven matches of the season remaining.
Meanwhile, Roberto Mancini's side still harbour top-four hopes and they were boosted on Sunday when goals by Roque Santa Cruz and Carlos Tevez helped them beat Fulham on the same day as Liverpool were losing at Manchester United.
While Spurs are involved in an FA Cup sixth-round replay against the Cottagers, City will leapfrog Harry Redknapp's team and move up to fourth in the table if they can take all three points from the midweek fixture.
Joleon Lescott will miss the chance to play against his former team-mates following his controversial transfer from Goodison Park to City last August as he has a hamstring injury while Wayne Bridge (groin) and Michael Johnson (knee) also miss out.
Source: DSG
Source: DSG