The average weekly pay at the Etihad Stadium is a staggering £100,764 which translates to an annual salary of £5,239,750.
City jump to top spot from third place last year, replacing Barcelona who are now fourth.
The LA Dodgers basketball team are second on the list, with their players averaging £93,380 per week, £4,855,783 annually.
Manchester United are in 12th place on the list, with average weekly wages of £75,423 (annual £3, 921,423). Last year they were 11th.
Bolton are placed at 112th in the list (£26,457 and £1,375,586), while Wigan come in at 168th (£21,338 and £1,109,600).
Manchester City Fixtures
Tuesday November 5
19:45 Champions League - Group D
Manchester City v CSKA Moscow
Sunday November 10
14:05 Premier League
Sunderland v Manchester City
Sunday November 24
13:30 Premier League
Manchester City v Tottenham
Wednesday November 27
19:45 Champions League - Group D
Manchester City v Plzen
Sunday December 1
16:10 Premier League
Manchester City v Swansea City
Wednesday December 4
20:00 Premier League
West Brom v Manchester City
Saturday December 7
15:00Premier League
Southampton v Manchester City