Reports in midweek linked City with the Olympiakos man, 34, but the City boss denies any interest in the 1998 World Cup winner.
"I don't read the papers but you can forget Christian Karembeu," he told the club's official website. "I think I was also linked with him four years ago as well, it seems to come along every four years."
But Keegan revealed he still wants on-loan Daniel Van Buyten, although he is not hopeful of capturing his services permanently.
"If there is one player in the world that I wish I could sign at the minute it is Daniel Van Buyten. I rate him that highly," revealed Keegan.
"I am totally impressed by him. I think he is an ideal number five. He has a good head on him and has leadership qualities. But at this moment in time he will not be coming here. We know he is worth money and we don't have any.
"It looks like we will lose him and I know that there are two other English clubs interested in him. I haven't totally given up hope as he is an outstanding player."