Trevor Sinclair has been dropped to the bench and Steve McManaman has a hamstring injury so Antoine Sibierski and Claudio Reyna are in.
Joey Barton has been given a place on the bench, along with Dutch defender Gerard Wiekens after Richard Dunne's ankle injury.
Former City winger, Mark Kennedy, described as Shaun Wright-Phillips as the home side's biggest threat, has missed out through injury.
Man City: Seaman, Jihai, Sommeil, Distin, Tarnat, Wright-Phillips, Bosvelt, Reyna, Sibierski, Anelka, Wanchope.
Subs: Weaver, Wiekens, Barton, Sinclair, Fowler.
Wolves: Oakes, Irwin, Butler, Craddock, Naylor, Cameron, Rae, Ince, Camara, Blake, Miller.
Subs: Murray, Kachloul, Okoronkwo, Sturridge, Newton.