Former Inter Milan star Balotelli, who was racially abused by Juventus supporters last season, may not travel.
Though City aim to top group A, Tevez - who had a transfer request rejected by the club this week - is one of many senior players expected to be rested.
Balotelli, 20, was also targeted by hardcore Italy fans during a friendly in November against Romania in Austria.
Without the Italian and Tevez, Mancini would be left with Emmanuel Adebayor and Jo as his senior strikers - Roque Santa Cruz is not on their squad list for the Europa League.
Can City's second-XI win in Turin?
Tevez returned to work on Tuesday after a short break to take part in a training session at the club's Carrington training complex.
His advisor, Kia Joorabchian, insists that Tevez is prepared to play for City
despite the 26-year-old Argentina striker stating he wants to leave as he feels the club reneged on promises which were unrelated to money.
City and Polish side Lech Poznan are already through to the next stage of the tournament with Juventus, now second in Serie A, eliminated.
City and England defender Micah Richards thinks the players who start against Juventus will look to show Mancini they are worthy of a regular starting place.
"We want to go there to win,"
Richards told the club's website.
"This game is for players who've not really played that often."
Source: BBC Sport
Source: BBC Sport