The strike pair will lead a City line-up that remains the same for the third game in succession.
That also means there is no place for Bradley Wright-Phillips, who scored just four minutes into his Premiership debut as a substitute in the 3-2 defeat at Middlesbrough on Monday.
"Nicolas Anelka comes back into the squad, but he will be on the bench along with Bradley Wright-Phillips," City boss Kevin Keegan told the official club website.
"I think it would be unfair to leave out either Robbie or Jon as they have both been doing so well."
Let's hope they have more luck in front of goal than Paulo Wanchope in last season's visit of Spurs, when the Costa Rican missed a host of chances as City somehow failed to win, drawing 0-0.