The 20-year-old Italian this weekend irked manager Roberto Mancini, who hauled the striker off after he attempted a trick shot in the club's friendly against the Los Angeles Galaxy.
De Jong, who was particularly demonstrative in his remonstrations with Balotelli at the time, said in comments quoted in The Guardian: "I've played with some strange characters in the past but it's the first time I have seen that.
"It is frustrating, and he has to iron out those issues otherwise it will be a waste of his talent. He has to realise that now.
"All his team-mates are here to help him but he's his own person and he is the only one who can change his ways."
David Beckham, meanwhile, has stuck up for Balotelli in the ongoing row over his ill-advised back heel in Los Angeles.
"I have watched it back a few times and from his mannerisms I believe he thought he was offside," said the former England skipper.
"Mario has been a great player for quite a few years and he is still very young. He will continue to get better I am sure.
"But it doesn't matter whether you think it was offside or not. There are a lot of young kids watching these teams and great players who come out here.
"You have to be professional and score the goal."
Source: Team Talk
Source: Team Talk