Ahead of Tuesday night's Capital One Cup semi-final second leg which should see City book their place in their first final of the season, Manuel Pellegrini's men are priced up at an industry-best price to win all four competitions they are in.
City, who currently sit second in the Premier League a point behind leaders Arsenal, are also through to the last 16 of the Champions League where they will meet Barcelona, the fourth round of the FA Cup where they will host Watford.
They are 6-0 up on West Ham heading into Tuesday's second leg of the League Cup with Manchester United or Sunderland lying in wait at Wembley.
To win the Quadruple, which Pellegrini was eyeing last week, City would need to play at least 30 more games this season.
Manuel Pellegrini: "We know that during the season, with injuries and the amount of games you have to play, it is very difficult.
"That's why nobody has done it before. But I think we must have the mentality to try to do it."