Aguero missed the draws against Stoke and Sunderland which have seen City fall five points behind Manchester United with just seven matches of the campaign remaining.
But no matter how poor the odds, Aguero said City will not throw in the towel, insisting: "This is no time for moping, I've said it before and I'll say it again - we are going to fight until the end."
The derby encounter at the Etihad Stadium on April 30, which for so long has looked like a title decider, is now going to be must-win at best for the Blues.
And Aguero told his official website: "That's our collective goal and I'm fully committed to it."
Aguero's recent absence has been particularly poorly timed. Of manager Roberto Mancini's other striking options, Edin Dzeko is presently in a poor run of form, Mario Balotelli's increasing erratic behaviour is casting a shadow over the club and Carlos Tevez has not appeared fully fit since returning to the fold.
And how City's £38million record signing ended up being sidelined has been a matter of debate since Mancini revealed a week ago that Aguero had been ruled out with a "stupid" injury.
Now, as he closes in on full fitness ahead of Sunday's trip to Arsenal, Aguero has decided to set the record straight.
"During the match against Chelsea, I injured my ankle and it was sprayed with a topical anaesthetic that caused a burn on the upper part of my right foot," said Aguero. "The injury worsened after a few days and when boils appeared I was told I wouldn't play against Stoke and then against Sunderland.
"You can imagine how I felt, being out of playing condition when my team is trying to take the championship. It's always worse from the bench."
Source: PA
Source: PA